EFFECT OF INFUSION OF A COMBINATION OF TEMU IRENG, TEMULAWAK, KENCUR, GINGER ON ERYTHROCYTE COUNT AND HEMATOCRIT LEVELS IN ANEMIA WHITE RATS

Authors

  • Indira Pipit Miranti STIKes Ibnu Sina Ajibarang
  • Eko Hidayaturrohman Khumaeni STIKes Ibnu Sina Ajibarang
  • Windy Risa Maghfira STIKes Ibnu Sina Ajibarang
  • Gunawan Gunawan Universitas Muhammadiyah Purwokerto
  • Jaka Wijaya Kusuma Universitas Bina Bangsa

DOI:

https://doi.org/10.53067/ijomral.v4i1.288

Keywords:

Anemia, Eritrosit, Hematokrit, Infusa

Abstract

Anemia is a condition in which the body experiences a decrease in hemoglobin levels, erythrocyte count, and hematocrit levels. The rhizomes of temu black, temulawak, kencur and ginger, contain compounds that have antioxidant and anti-inflammatory activities that can prevent and repair damage from oxidative stress in the body that causes anemia. This study aims to determine the effect and optimal frequency of infusion administration of a combination of temu ireng, temulawak, kencur, and ginger on erythrocyte count and hematocrit levels in white rats of the wistar strain anemia. The method used is experimental research with a pre-post-test control design. The four rhizomes used in this study contribute to the treatment of anemia. The isoflavone content in black temu and curcumin in curcumin in curcumin can prevent damage to erythrocytes due to oxidative stress of sodium nitrite exposure. Other ingredients such as Ethyl p-methoxycinnamate in ginger act as an anti-inflammatory by reducing the production of cytokines IL-1 and TNF-ɑ. Then the content of 6-gingerol in ginger can stop the formation of hepcidin which inhibits the absorption of iron, so that the process of forming red blood cells can continue in the bone marrow. It can be concluded that the combination of infusion of temu black, temulawak, kencur and ginger can increase the number of erythrocytes and hematocrit levels in anemia white rats. Meanwhile, the optimal frequency in increasing the number of erythrocytes and hematocrit levels occurred in the P2 group with a frequency of administration 2 times a day.

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References

Ardiansyah, S., Sielvi, H., Handayani, L., dan Wulandari, F. (2022) ‘Pengaruh Infusa Kulit Buah Naga Putih (Hylocereus undatus) Terhadap Kadar Hemoglobin, Jumlah Eritrosit, dan Kadar Hematokrit Tikus Putih Anemia’, Medicra (Journal of Medical Laboratory Science/Technology), 5(2), 98–103. https://doi.org/10.21070/medicra.v5i2.1643

BPOM (2021) ‘Peraturan badan pengawas obat dan makanan nomor 18 tahun 2021 tentang pedoman uji farmakodinamik praklinik obat tradisional’, Badan Pengawas Obat dan Makanan RI, (1), pp. 15–24.

Danarsih, D. E., Kusumawardani, A. M. and Ariningtyas, R. E. (2023) ‘Hubungan Antara Indeks Massa Tubuh dan Kadar Hemoglobin pada Remaja Putri’, Jurnal Indonesia Sehat, 2(2), pp. 53–58.

Fadila, R. I. et al. (2024) ‘Analisis Aktivitas Antioksidan Pada Temulawak ( Curcuma xanthorrhiza Roxb .) Dan Jahe Merah ( Zingiber officinale var Rubrum ) : Kajian Mendalam Antioxidant Activity Analysis Of Temulawak ( Curcuma xanthorrhiza Roxb .) And Red Ginger ( Zingiber officinale’, Medula, 14(April), pp. 719–724.

Kemenkes, RI. (2017) Formularium Ramuan Obat Tradisional Indonesia, Kemenkes RI. Jakarta: Kemenkes RI.

Kemenkes, RI. (2022) Laporan Kinerja Tahun 2022. Jakarta: Kemenkes RI.

Ooi, S. L. et al. (2022) ‘Polyphenol-Rich Ginger (Zingiber officinale) for Iron Deficiency Anaemia and Other Clinical Entities Associated with Altered Iron Metabolism’, Molecules, 27(19). https://doi.org/10.3390/molecules27196417

Puspita, R., Harnis, ZE., Harahap, N. (2023) ‘Penyuluhan Pemanfaatan Tanaman Obat Keluarga (Temu Hitam) Yang Mengandung Antioksidan Untuk Meningkatkan Daya Tahan Tubuh Masyarkat Simalingkar’, Jurnal Pengabdian Masyarakat Putri Hijau, 3(1), pp. 47–50. https://doi.org/10.36656/jpmph.v3i1.1151

Ramos-González, E. J. et al. (2024) ‘Relationship between inflammation and oxidative stress and its effect on multiple sclerosis’, Neurologia, 39(3), pp. 292–301. https://doi.org/10.1016/j.nrl.2021.10.003

Sandy, P., dan Susilawati, Y. (2021) ‘Review Artikel: Manfaat Empiris dan Aktivitas Farmakologi Jahe Merah (Zingiber officinale Roscoe), Kunyit (Curcuma domestica Val.) dan Kencur (Kaempferia galanga L.)’, Farmaka, 19(2), pp. 36–47.

Sari, D. and Nasuha, A. (2021) ‘Kandungan Zat Gizi, Fitokimia, dan Aktivitas Farmakologis pada Jahe (Zingiber officinale Rosc.): Review’, Tropical Bioscience: Journal of Biological Science, 1(2), pp. 11–18. https://doi.org/10.32678/tropicalbiosci.v1i2.5246

Setyarini, E. et al. (2023) ‘Pengaruh Pemberian Ekstrak Okra (Abelmoschus Esculentus) terhadap Peningkatan Jumlah Eritrosit dan Kadar Hemoglobin (Hb) Darah Tikus Putih Jantan (Rattus Norvegicus) Anemia yang Diinduksi Natrium Nitrit (NaNO2)’, ARTERI : Jurnal Ilmu Kesehatan, 4(3), pp. 133–137. https://doi.org/10.37148/arteri.v4i3.254

Taherkhani, S., Suzuki, K. and Castell, L. (2020) ‘A short overview of changes in inflammatory cytokines and oxidative stress in response to physical activity and antioxidant supplementation’, Antioxidants, 9(9), pp. 1–18. https://doi.org/10.3390/antiox9090886

Yumita, A., Dwitiyanti, D. and Ermawati, P. (2022) ‘Aktivitas Antikonvulsan Rimpang Temu Ireng (Curcuma aeruginosa Roxb.) Pada Tikus Putih Jantan Menggunakan Elektrokonvulsiometer’, Jurnal Ilmiah Farmasi Farmasyifa, 5(1), pp. 41–51. https://doi.org/10.29313/jiff.v5i1.8829

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Published

2025-01-01

How to Cite

Miranti, I. P. ., Khumaeni, E. H. ., Maghfira, W. R. ., Gunawan, G., & Kusuma, J. W. . (2025). EFFECT OF INFUSION OF A COMBINATION OF TEMU IRENG, TEMULAWAK, KENCUR, GINGER ON ERYTHROCYTE COUNT AND HEMATOCRIT LEVELS IN ANEMIA WHITE RATS. International Journal of Multidisciplinary Research and Literature, 4(1), 12–19. https://doi.org/10.53067/ijomral.v4i1.288